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People can 'suppress' hay fever with three years of pollen pills or injections

Patients blighted by hay fever could markedly reduce symptoms for several years after a three-year course of treatment, but not after two years of treatment, researchers have found. Research from Imperial College London published in JAMA found immunotherapy treatment over a three year period was significantly better than that of only two years.

 

Comment from Allergy UK’s Head of Clinical Services, Amena Warner:

Allergy UK has many calls to its helpline from people looking for advice about hay fever (allergic rhinitis) symptoms and also information on how and where they may be able to receive immunotherapy.

Immunotherapy is a treatment option for those suffering with the most severe hay fever symptoms, that have not been adequately controlled by previously prescribed or over the counter anti-allergy medication. 

Subcutaneous (injection) immunotherapy has been used for many, many years (60 +), but sublingual immunotherapy (under the tongue) has been a more recently introduced treatment option. Both sublingual and subcutaneous immunotherapy are used for three consecutive years, and there have been many research studies to show its disease modifying effects after three years. 

Immunotherapy is a high cost medication, so it was important for this research study to explore whether the three year course could be reduced to two years, and still have the same effectiveness. Benefits of reducing this treatment period would include time that the patient needed to have the course, as well as the financial savings if there was one year less of treatment. Unfortunately this trial showed that two years was not long enough to achieve the same effectiveness as a three year course of treatment. 

 

PRESS RELEASE FROM IMPERIAL COLLEGE LONDON:

People can 'suppress' hay fever with three years of pollen pills or injections 

Patients blighted by hay fever could markedly reduce symptoms for several years after a three-year course of treatment, but not after two years of treatment, researchers have found. 

Previous research has shown that a type of immunotherapy that exposes patients to increasing amounts of grass pollen over time is an effective way to reduce severe symptoms in the long term. 

But in a new study, published today in the journal JAMA, scientists from Imperial College London have found that a two-year course of treatment is not enough to achieve lasting effects, bolstering previous findings that more time is needed taking the medication to get lasting benefit. The research was funded by the Immune Tolerance Network, supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA. 

"You treat patients for three years and then they have a big improvement in their hay fever for several years afterwards," said Professor Stephen Durham, Head of Allergy and Clinical Immunology at the National Heart and Lung Institute at Imperial and clinical lead for allergy services at Royal Brompton Hospital, who led the study. 

"Exposing people to grass pollen in this way is a very effective treatment for people who really have debilitating hay fever." 

Hay fever, or seasonal allergic rhinitis, affects as many as one in four people in the UK, leaving sufferers with bouts of sneezing, runny nose and itchy eyes -- all of which can affect work, school and leisure during the summer months when the pollen count soars. 

In the majority of cases in the UK the culprit is grass pollen, which the body recognises as an invader, launching an immune response. 

A number of over the counter medications are available, such as nasal sprays and antihistamine tablets, but patients with more severe symptoms can be treated with immunotherapy, using a similar approach to the one trialled in children with peanut allergies. 

By exposing their immune system to grass pollen extracts over time they are able to build up their resistance, either through injections or a pill containing pollen extract. 

The latest study involved patient volunteers at Royal Brompton Hospital in London, which runs a world-class allergy clinic, researchers tested the effectiveness of two immunotherapies prescribed by the NHS which use grass pollen extract: an injection and a pill taken under the tongue. 

It was the first head to head trial of the two therapies, in which researchers set out to see if a two-year treatment could achieve the same long-lasting benefits to patients as seen with three-years of immunotherapy, potentially leading to clinical cost savings. 

The study was a double blind, placebo-controlled trial in which 106 patients were randomised to one of three treatment groups: injection, tablets and placebo. 

Patients had moderate to severe hay fever and were administered either the daily oral treatment, weekly injections for 15 weeks followed by monthly boosters, or a placebo. A total of 92 patients completed the study. 

After a two year course of treatment, the results showed that both therapies were effective at tackling symptoms, with patients reporting a dramatic improvement in their quality of life. However, one year after patients had stopped taking the medication the effects were no better than the placebo group. 

"Hay fever causes major impairment of sleep, work and school performance and leisure activities during what for most of us is the best time of the year," said Professor Durham. 

"Most people respond to the usual antihistamines and nasal sprays, although there is a portion who do not respond adequately or who have unacceptable side effects to the treatment." 

Describing the current findings, Professor Durham said: "This study shows that whereas both immunotherapy treatments were highly effective, two years of treatment was insufficient for long-term benefits. 

"Clinicians and patients should continue to follow international guidelines that recommend a minimum of three years' treatment." 

Previous studies published by Imperial researchers have shown the long-lasting benefits of both immunotherapy injections and pills for severe hay fever - benefits which persist for at least two to three years after the treatment has stopped. 

Professor Durham added: "We have reconfirmed that both treatments are effective but that in order to get the long-term clinical benefits after stopping the treatment, you have to take it for three years." 

Researchers at Imperial have a long legacy with immunotherapy dating back to 1911, when a grass pollen injection treatment was first shown to be highly effective in treating hay fever.